Cyclin A and cyclin E as prognostic factors in early breast cancer

This thesis is based on the following papers, which are referred to in the text by their Roman numerals. Reliability of cyclin A assessment on tissue microarrays in breast cancer compared to conventional histological slides.67 and cyclin A as prognostic factors in early breast cancer. Which is the optimal cutoff value? Histopathol-Is cyclin A a prognostic factor in node negative breast cancer? In manuscript. ABBREVIATIONS AEC Amino-ethyl-carbazole BCSS Breast cancer specific survival Cdk Cyclin dependant kinase CI Confidence interval CIP Cdk interacting protein CKI Cyclin dependent kinase inhibitor CMF Cyclophosphamide, methotrexate, 5-fluorouracil DAB Diaminobenzidine DAPI 2-4-amidinophenyl-6-indolecarbamidine dihydrochloride DFS Disease-free survival DNA Deoxyribonucleic acid E2F E2 promotor binding factor EGF Epidermal growth factor ER Oestrogen receptor FAC 5-fluorouracil, adriamycin, cyclophosphamide FEC 5-fluorouracil, epirubicin, cyclophosphamide FISH Fluorescence in situ hybridization Her2 Human epidermal growth factor receptor 2 HR Hazard ratio IHC Immunohistochemistry INK4 Inhibitor of cdk4 KIP Cdk inhibitory protein LMW Low-molecular-weight MFS Metastasis free survival NHG Nottingham histological grade NNT Number needed to treat OS Overall survival PgR Progesterone receptor pRb The retinoblastoma gene product RNA Ribonucleic acid ROC Regionalt Onkologiskt Centrum RR Risk ratio SPF S-phase fraction TNM Tumour size, node, metastasis TMA Tissue microarray 9 INTRODUCTION